Regulation of total and regional spinal cord blood flow.

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Regulation of total and regional spinal cord blood flow.

Studies of the regulation of total spinal cord blood flow have been limited by methodology. Total flow has been difficult to measure and flow to the gray and white matter within the cord has not been previously assessed. We have used labeled microspheres to measure blood flow in the spinal cord. Our purpose was to examine the effects of several physiological stimuli on the regulation of blood f...

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Spinal cord blood flow and systemic blood pressure after experimental spinal cord injury in rats.

We looked at the relation between systemic arterial blood pressure and recovery from spinal cord injury by inducing both hypertension and hypotension in 25 rats randomly allocated to five equal groups. The rats received no injury, a mild (2.3-g), or a severe (53.0-g) spinal cord injury lasting 1 minute. We used the hydrogen clearance technique to measure spinal cord blood flow at the injury sit...

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Spinal cord blood flow following subarachnoid tetracaine.

Spinal cord and spinal dural blood flow in the cervical, thoracic and lumbosacral regions were measured in dogs using the radioactive microsphere technique. Measurements were taken before and 20 and 40 minutes after lumbar subarachnoid injection of one of the following: physiologic saline; tetracaine 20 mg or tetracaine 20 mg with epinephrine 200 micrograms. No significant change in spinal cord...

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Contrast enhanced ultrasound imaging for assessment of spinal cord blood flow in experimental spinal cord injury.

Reduced spinal cord blood flow (SCBF) (i.e., ischemia) plays a key role in traumatic spinal cord injury (SCI) pathophysiology and is accordingly an important target for neuroprotective therapies. Although several techniques have been described to assess SCBF, they all have significant limitations. To overcome the latter, we propose the use of real-time contrast enhanced ultrasound imaging (CEU)...

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Relation between spinal cord and epidural blood flow.

To test applicability of monitoring regional spinal cord blood flow by measuring regional epidural blood flow, both were simultaneously measured by the hydrogen clearance method in response to changes in PaCO2 and mean arterial blood pressure in rats anesthetized with pentobarbital. An excellent correlation was found between regional spinal and epidural blood flow over a physiological range of ...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1977

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.41.1.128